Sadhra S, Foulds I S
Institute of Occupational Health, University of Birmingham, Edgbaston, U.K.
Br J Dermatol. 1995 Jan;132(1):69-73. doi: 10.1111/j.1365-2133.1995.tb08627.x.
An ion-exchange fractionation technique for the separation of total resin acid and neutral fractions of unmodified colophony is described. The allergic potential of these fractions was assessed by patch testing colophony-sensitive individuals, and this showed that both the neutral components and the resin acids play an important role in colophony sensitization. A greater frequency of positive reactions was obtained using the 60% colophony patch test preparation compared with the currently recommended 20% colophony preparation. Furthermore, some individuals were found to produce positive reactions to only the neutral components in colophony. We suggest that the use of a colophony patch test battery comprising resin acids, neutrals, oxidized resin acid and some colophony derivatives, will facilitate detection of colophony-sensitive individuals. Moreover, we consider that this will help to provide a better estimate of the prevalence of colophony dermatitis, which is currently underestimated.
本文描述了一种用于分离未改性松香中总树脂酸和中性馏分的离子交换分馏技术。通过对松香敏感个体进行斑贴试验来评估这些馏分的过敏潜力，结果表明中性成分和树脂酸在松香致敏中均起重要作用。与目前推荐的20%松香斑贴试验制剂相比，使用60%松香斑贴试验制剂获得的阳性反应频率更高。此外，发现一些个体仅对松香中的中性成分产生阳性反应。我们建议使用包含树脂酸、中性成分、氧化树脂酸和一些松香衍生物的松香斑贴试验组合，将有助于检测松香敏感个体。此外，我们认为这将有助于更好地估计目前被低估的松香性皮炎患病率。
