Oyelami S A, Olaleye O D, Oyejide C O, Omilabu S A, Fatunla B A
Baptist Hospital, Saki, Oyo State, Nigeria.
Rev Roum Virol. 1994 Jan-Jun;45(1-2):25-30.
An unusual outbreak of post-vaccination reactions to 17D yellow fever vaccine occurred at Shaki, Nigeria, in May 1987. Twenty-five of the affected people were treated at the Baptist Hospital Shaki. The patients presented with rapidly progressing swelling of the left arm with associated fever and other constitutional symptoms few hours after inoculation with the vaccine. Some of the patients developed gangrene of the affected limb, five of them went into coma and died. Poor hygiene and improper handling of vaccine as well as contamination of vaccine from the source are possible causes. A review of vaccine delivery strategies especially at local community levels; sound training, supervision of vaccinators and health education are strongly recommended to prevent reoccurrence of similar reactions.
1987年5月，尼日利亚沙基发生了一起不同寻常的17D黄热病疫苗接种后反应疫情。25名感染者在沙基浸礼会医院接受治疗。患者在接种疫苗几小时后，左臂迅速肿胀，并伴有发热和其他全身症状。部分患者受影响肢体发生坏疽，其中5人陷入昏迷并死亡。卫生条件差、疫苗处理不当以及疫苗源污染可能是病因。强烈建议对疫苗接种策略进行审查，特别是在当地社区层面；提供完善的培训、对接种人员的监督以及健康教育，以防止类似反应再次发生。
