Adu F D, Adeniji J A, Tomori O, Adelasoye A
Department of Virology, College of Medicine, University of Ibadan, Nigeria.
Rom J Virol. 1993 Jan-Jun;44(1-2):3-7.
An outbreak of yellow fever in Ipetu-Ijesa, Nigeria, was confirmed by serological test and virus isolation. Serologically testing of subjects 12 weeks after an emergency mass vaccination following the outbreak showed a high degree of cross reactivity between yellow fever virus and seven other group B flaviviruses. There was no significant difference in the prevalence of neutralizing antibodies to yellow fever vaccine and wild virus among the vaccinated subjects. These findings are attributed to the probable hyperactivity and an all time exposure to yellow fever virus in circulation in the studied area.
尼日利亚伊佩图-伊杰萨发生的黄热病疫情通过血清学检测和病毒分离得到确认。疫情爆发后进行紧急大规模疫苗接种12周后对受试者进行血清学检测，结果显示黄热病毒与其他7种B组黄病毒之间存在高度交叉反应。在接种疫苗的受试者中，针对黄热病疫苗和野生病毒的中和抗体流行率没有显著差异。这些发现归因于研究区域可能存在的黄热病毒高活性以及长期暴露于循环中的黄热病毒。
