Jensen S L, Kühl C, Nielsen O V
Scand J Gastroenterol Suppl. 1976;37:47-51.
Oral glucose tolerance tests (OGTT) were performed in 6 healthly, unimmunosuppressed pigs before and after heterotopic pancreatic transplantation and total pancreatectomy. Mean survival time after grafting was 55 days. Mean basal concentrations of glucose and insulin in serum were significantly higher after grafting and total pancreatectomy (p less than 0.01), but the insulin-to-glucose ratio was unaffected. The tolerance to oral glucose decreased after grafting and total pancreatectomy (p less than 0.01), even though the insulin levels in serum during OGTT were higher tp less than 0.01). This finding was also reflected in the insulinogenic index, which was almost twice as large after transplantation (p less than 0.01) as before. The decreased oral glucose tolerance might be explained by drainage of the transplanted pancreas into the systemic circulation instead of the portal vein.
对6头健康、未接受免疫抑制的猪在异位胰腺移植和全胰切除术前、后进行了口服葡萄糖耐量试验（OGTT）。移植后的平均存活时间为55天。移植和全胰切除术后血清中葡萄糖和胰岛素的平均基础浓度显著升高（p<0.01），但胰岛素与葡萄糖的比值未受影响。移植和全胰切除术后口服葡萄糖耐量降低（p<0.01），尽管口服葡萄糖耐量试验期间血清胰岛素水平较高（p<0.01）。这一发现也反映在胰岛素生成指数上，移植后胰岛素生成指数几乎是移植前的两倍（p<0.01）。口服葡萄糖耐量降低可能是由于移植的胰腺引流至体循环而非门静脉所致。
