Jensen S L, Nielsen O V, Kühl C
Diabetologia. 1976 Dec;12(6):617-20. doi: 10.1007/BF01220640.
The insulin responses to an oral glucose tolerance test (OGTT) and in intravenous glucose infusion (IVGI), designed to copy the changes in serum glucose concentrations found during OGTT, were measured in four pigs before and after heterotopic pancreatico-duodenal allotransplantation and total pancreatectomy. After transplantation and total pancreatectomy a remarkable hyperinsulinaemia occurred during OGTT and IVGI, reflected by an almost two-fold increment in the insulinogenic index after transplantation. This finding might be explained by drainage of the transplanted pancreas into the systemic circulation instead of the portal vein. The magnitude of the enteral stimulus, i. e. the incretin effect on insulin secretion during OGTT was unchanged after transplantation, suggesting that the incretin effect is not mediated by neural influences upon the endocrine pancreas.
在四只猪进行异位胰十二指肠同种异体移植和全胰切除术前和术后，测量了它们对口服葡萄糖耐量试验（OGTT）以及旨在模拟OGTT期间血清葡萄糖浓度变化的静脉葡萄糖输注（IVGI）的胰岛素反应。移植和全胰切除术后，OGTT和IVGI期间出现了显著的高胰岛素血症，移植后胰岛素生成指数几乎增加了两倍就反映了这一点。这一发现可能是由于移植的胰腺引流到体循环而非门静脉所致。移植后，肠内刺激的强度，即OGTT期间肠促胰岛素对胰岛素分泌的作用没有改变，这表明肠促胰岛素作用不是由神经对内分泌胰腺的影响介导的。
