Bulstra-Ramakers M T, Huisjes H J, Visser G H
Department of Obstetrics and Gynaecology, University Hospital, Groningen, The Netherlands.
Br J Obstet Gynaecol. 1995 Feb;102(2):123-6. doi: 10.1111/j.1471-0528.1995.tb09064.x.
To study the effects of addition of 3 g eicosapentaenoic acid daily to the diet, on recurrence rate of intrauterine growth retardation and pregnancy induced hypertension in a high risk population.
Prospective, double blind, randomised multicentre study. Eicosapentaenoic acid or placebo were given from 12 to 14 weeks of gestation onwards.
University Hospital and regional hospitals in the north of the Netherlands.
Sixty-three women with a history of intrauterine growth retardation (birthweight < 10th centile) with or without pregnancy induced hypertension in the previous pregnancy.
Birthweight centiles and signs of pregnancy induced hypertension in current pregnancy.
One-third of the women developed pregnancy induced hypertension and one-third of the infants had a birthweight below the 10th centile. There were no differences between eicosapentaenoic acid and placebo group.
Addition of 3 g eicosapentaenoic acid daily does not prevent recurrence of intrauterine growth retardation or pregnancy induced hypertension in a high risk population.
