Ekberg M, Bergentz S E, Hedner U, Nilsson I M
Scand J Urol Nephrol. 1976;10(1):56-62. doi: 10.3109/00365597609179656.
Fibrin/fibrinogen degradation products (FDP) were determined in concentrated as well as unconcentrated urine in 29 patients undergoing renal transplantation. When determined in unconcentrated urine, FDP was found for 3-4 weeks after an uneventful transplantation, compared with 12 weeks when determined in concentrated urine. After acute rejection episodes FDP was found in unconcentrated urine, but remained in the concentrated urine for 8 weeks longer when concentrated urine was used for determination. In early chronic rejection and glomerulonephritis, FDP appeared as a sign of glomerular lesion in concentrated urine before it was found in unconcentrated urine. It was concljded that the presence of FDP in concentrated urine is a diagnostic tool of value particular in detecting early glomerular lesions caused by chronic rejection or glomerulonephritis.
对29例接受肾移植的患者的浓缩尿和非浓缩尿中的纤维蛋白/纤维蛋白原降解产物（FDP）进行了测定。在非浓缩尿中进行测定时，移植顺利后3至4周可检测到FDP，而在浓缩尿中进行测定时，这一时期为12周。急性排斥反应发作后，在非浓缩尿中可检测到FDP，但当使用浓缩尿进行测定时，FDP在浓缩尿中持续存在的时间要长8周。在早期慢性排斥反应和肾小球肾炎中，FDP在非浓缩尿中被发现之前，在浓缩尿中就已作为肾小球病变的一个迹象出现。得出的结论是，浓缩尿中FDP的存在是一种有价值的诊断工具，尤其在检测由慢性排斥反应或肾小球肾炎引起的早期肾小球病变方面。
