Edward M
Department of Dermatology, University of Glasgow, Scotland, UK.
Curr Opin Oncol. 1995 Mar;7(2):185-91. doi: 10.1097/00001622-199503000-00015.
Recent investigations have reported changes in the expression of cell surface adhesion molecules associated with melanoma progression from in situ to invasive to metastatic tumors, including the upregulation of the integrins alpha v beta 3, alpha 3 beta 1, alpha 4 beta 1, and alpha 5 beta 1, downregulation of alpha 6 beta 1, and enhanced expression of intercellular adhesion molecule-1, MUC18, and CD44. Current research is now focused on the function of these adhesion molecules in facilitating melanoma invasion, metastasis and evasion of lysis by effector cells, and the mechanisms involved in controlling the adhesion molecule activation state and signal transduction.
最近的研究报告了与黑色素瘤从原位肿瘤进展为侵袭性肿瘤再到转移性肿瘤相关的细胞表面粘附分子表达的变化，包括整合素αvβ3、α3β1、α4β1和α5β1的上调，α6β1的下调，以及细胞间粘附分子-1、MUC18和CD44的表达增强。目前的研究集中在这些粘附分子在促进黑色素瘤侵袭、转移以及逃避效应细胞裂解方面的功能，以及控制粘附分子激活状态和信号转导所涉及的机制。
