Andersson K, Blum M, Chen Y, Eneroth P, Gross J, Herrera-Marschitz M, Bjelke B, Bolme P, Diaz R, Jamison L
Dr A. A. Fishberg Center in Neurobiology, Mount Sinai School of Medicine, Mount Sinai Hospital, New York, USA.
Neuroreport. 1995 Jan 26;6(2):375-8. doi: 10.1097/00001756-199501000-00036.
The present investigation was undertaken in order to study the long-term effects of perinatal asphyxia on basic fibroblast growth factor (bFGF) gene expression and the number of dopamine nerve cell bodies in the mesencephalon of the rat. Asphyxia was induced during birth for 19-20 min. A 30% increase in the number of tyrosine-hydroxylase immunoreactive (TH-IR) nerve cell bodies (i.e. dopamine-containing neurones) as well as a 50% increase in bFGF gene expression following asphyxia was found in the substantia nigra/ventral tegmental area 4 weeks after birth. The increase in bFGF mRNA levels may underlie the increase found in the number of dopamine cell bodies. The present results indicate that asphyxia during birth can prime the long-term development of the central nervous system.
本研究旨在探讨围产期窒息对大鼠中脑碱性成纤维细胞生长因子（bFGF）基因表达及多巴胺神经细胞体数量的长期影响。出生时诱导窒息19 - 20分钟。出生4周后，在黑质/腹侧被盖区发现酪氨酸羟化酶免疫反应性（TH-IR）神经细胞体（即含多巴胺的神经元）数量增加30%，窒息后bFGF基因表达增加50%。bFGF mRNA水平的增加可能是多巴胺细胞体数量增加的基础。目前的结果表明，出生时窒息可引发中枢神经系统的长期发育。
