Krug F, Bäurle J, Grüsser-Cornehls U
Department of Physiology, Freie Universität Berlin, Germany.
Histol Histopathol. 1995 Jan;10(1):105-9.
Reorganization of cerebellar circuitry due to specific cell loss in Weaver mutants causes physiological and morphological alterations in the terminal domains of the GABAergic cerebellar corticovestibular projections. In this study sizes of anti-GAD immunopositive terminals in the dorsal part of the lateral vestibular nucleus (dLVN) of normal mice and Weaver mutants were quantified morphometrically. In anti-GAD-immunoreacted material terminal sizes in the dLVN of Weaver exceed significantly those of coprocessed wildtypes. This suggests that the cerebellar disturbances in Weaver predispose the normal synaptic remodelling observed in wildtypes towards the formation of enlarged terminals.
由于韦弗突变体中特定细胞的缺失导致小脑回路的重组，引起了小脑GABA能皮质前庭投射终末区域的生理和形态学改变。在本研究中，对正常小鼠和韦弗突变体的外侧前庭核背侧部分（dLVN）中抗谷氨酸脱羧酶（GAD）免疫阳性终末的大小进行了形态计量学量化。在抗GAD免疫反应材料中，韦弗突变体dLVN中的终末大小显著超过同时处理的野生型。这表明韦弗突变体中的小脑紊乱使野生型中观察到的正常突触重塑倾向于形成增大的终末。
