Yoshioka K, Maki S
Department of Pediatrics, Kinki University School of Medicine, Osaka-sayama, Japan.
Histol Histopathol. 1995 Jan;10(1):203-12.
This overview summarizes recent information concerning the biopathology of mesangial cell proliferation and matrix expansion which constitute fundamental features in human IgA nephritis. The currently available knowledge, mainly stemming for immunohistochemical observation of human materials, experimental investigations with laboratory animals, and mesangial cell culture studies, emphasizes the importance of cell to cell, cell to soluble factors, and cell to matrix interactions. Mesangial cells, activated by cytokines and growth factors, express adhesion molecules, stimulate proliferation both of themselves and neighbouring cells, and synthesize extracellular matrix. Matrix components, in turn, may influence the behaviour and proliferation activity of mesangial cells, or act as a receptor or reservoir for growth factors. Expression of protooncogenes, regulating cell proliferation and apoptosis, by glomerular cells could be associated with persistent cell replication and chronic tissue damage. These disease processes seem to be common to a group of diseases termed chronic inflammatory proliferative disorders.
本综述总结了有关系膜细胞增殖和基质扩张的生物病理学的最新信息，这些是人类IgA肾病的基本特征。目前可得的知识主要源于对人体材料的免疫组织化学观察、实验动物的实验研究以及系膜细胞培养研究，强调了细胞间、细胞与可溶性因子间以及细胞与基质间相互作用的重要性。被细胞因子和生长因子激活的系膜细胞表达黏附分子，刺激自身及邻近细胞的增殖，并合成细胞外基质。反过来，基质成分可能影响系膜细胞的行为和增殖活性，或充当生长因子的受体或储存库。肾小球细胞中调节细胞增殖和凋亡的原癌基因的表达可能与持续的细胞复制和慢性组织损伤有关。这些疾病过程似乎是一组称为慢性炎症增殖性疾病的共同特征。
