Solov'eva E V, Kulikov S V, Khar'kovskiĭ A O, Bogdanov E G
Eksp Klin Farmakol. 1994 Nov-Dec;57(6):20-2.
The enkephalin analogue peptide IKB-901 containing epsilon-ACA and cysteine with the modified S-end shows an analgetic activity in rats (1 micron, intrathecally and 5 mg/kg intravenously) and in cats (0.35 and 0.7 mg/kg intravenously). Naloxone (0.1 mg/kg) prevents the analgetic effect of peptide. The coadministration of the peptide and the enkephalinase inhibitor D-phenylalanine (0.35 and 10 mg/kg, respectively) enhances analgesia and displays an antihypertensive effect in nociceptive stimulation.
含有ε-ACA和具有修饰S端的半胱氨酸的脑啡肽类似物肽IKB-901在大鼠（鞘内注射1微克和静脉注射5毫克/千克）和猫（静脉注射0.35和0.7毫克/千克）中显示出镇痛活性。纳洛酮（0.1毫克/千克）可预防该肽的镇痛作用。该肽与脑啡肽酶抑制剂D-苯丙氨酸（分别为0.35和10毫克/千克）共同给药可增强镇痛作用，并在伤害性刺激中显示出降压作用。
