暴露于222Rn子体的矿工中，辐射诱发的支气管发育异常。
Bronchial dysplasia induced by radiation in miners exposed to 222Rn progeny.
作者信息
Michaylov M A, Pressyanov D S, Kalinov K B
机构信息
Department of Radiation Hygiene, Hygienic and Epidemiology Inspection, Ministry of Health, Sofia-Bouchovo, Bulgaria.
出版信息
Occup Environ Med. 1995 Feb;52(2):82-5. doi: 10.1136/oem.52.2.82.
OBJECTIVES
To investigate whether sputum cytology can be used to monitor epithelial cell changes in groups at high risk of lung cancer from exposure to radiation.
METHODS
Dysplasia of bronchial cells was investigated by means of sputum cytology in a group of 434 underground miners. 100 of them were not exposed, and 334 were exposed to 222Rn progeny at cumulative exposures < 450 working level months.
RESULTS
The frequency of dysplasia in the exposed group was significantly higher than that in the not exposed group (P < 0.0001), and an exposure-response relation was found. This relation was different for smokers and non-smokers.
CONCLUSIONS
Possibly the frequencies of dysplasia could be used to assess past exposures of groups of miners. This approach could be applied to cases where data on radiation monitoring are not available or are very scarce.
目的
研究痰细胞学检查是否可用于监测因辐射暴露而处于肺癌高危组的上皮细胞变化。
方法
通过痰细胞学检查对一组434名地下矿工的支气管细胞发育异常情况进行研究。其中100人未暴露于辐射，334人累积暴露于小于450工作水平月的222Rn子体。
结果
暴露组发育异常的频率显著高于未暴露组（P < 0.0001），且发现了暴露-反应关系。吸烟者和非吸烟者的这种关系有所不同。
结论
发育异常的频率可能可用于评估矿工群体过去的暴露情况。这种方法可应用于无法获得或辐射监测数据非常稀少的情况。
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