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[处于对数生长期的放射敏感突变型酵母受239Puα粒子照射时的相对生物学效应]

[The RBE of 239Pu alpha particles for radiosensitive mutant yeast irradiated at a logarithmic growth stage].

作者信息

Petin V G, Petin D V

出版信息

Radiats Biol Radioecol. 1995 Mar-Apr;35(2):131-6.

PMID:7757175
Abstract

The relative biological efficiency (RBE) of alpha particles for wild-type yeast cells and radiosensitive mutants exposed in stationary and logarithmic stages of growth was compared. A correlation between the RBE of densely ionizing radiation and cell repair capacity was supported for plateau-phase cultures. It was shown for the first time that RBE of alpha particles for cells exposed in logarithmic stage was less than the RBE for stationary cells for all strains studied. For the most mutant cells RBE of alpha particle was closed to unity, i.e. cell radiosensitivity was almost identical for sparsely and densely ionizing radiation. Possible reasons for the observed radiation responses are discussed.

摘要

比较了α粒子对处于生长静止期和对数期的野生型酵母细胞和辐射敏感突变体的相对生物效能(RBE)。对于平台期培养物,支持了密集电离辐射的RBE与细胞修复能力之间的相关性。首次表明,对于所有研究的菌株,对数期暴露细胞的α粒子RBE小于静止期细胞的RBE。对于大多数突变细胞,α粒子的RBE接近于1,即稀疏和密集电离辐射的细胞放射敏感性几乎相同。讨论了观察到的辐射反应的可能原因。

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