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[评估潜在致死性和亚致死性损伤的修复在密集电离辐射相对生物效应中的作用]

[The evaluation of the role of recovery from potentially lethal and sublethal damages in the RBE of densely ionizing radiation].

作者信息

Shvedenko V I, Petin V G

机构信息

Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia.

出版信息

Radiats Biol Radioecol. 2000 Jul-Aug;40(4):416-9.

Abstract

The new data confirming the relations between RBE and recovery of cells are presented. The quantitative evaluation of the contribution of potentially lethal and sublethal damage recovery in radiosensitivity of cells of various origin after exposure to low- and high-LET ionizing radiation was carried out. The conclusion about the greater contribution of potentially lethal damage recovery in the magnitude of RBE in comparison with sublethal damage recovery was made.

摘要

本文展示了证实相对生物学效应(RBE)与细胞恢复之间关系的新数据。对不同来源的细胞在受到低传能线密度(LET)和高LET电离辐射后,潜在致死损伤和亚致死损伤恢复对放射敏感性贡献的定量评估得以开展。得出了关于潜在致死损伤恢复在RBE大小方面比亚致死损伤恢复贡献更大的结论。

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