林丹对兔和大鼠妊娠的影响。
Effect of lindane on pregnancy in the rabbit and rat.
作者信息
Palmer A K, Bottomley A M, Worden A N, Frohberg H, Bauer A
出版信息
Toxicology. 1978 Mar;9(3):239-47. doi: 10.1016/0300-483x(78)90006-9.
PMID:77574
Abstract
There was no evidence of any teratogenic effect of lindane when administered during pregnancy at levels equivalent to 5, and 15 mg/kg body weight to New Zealand White rabbits from days 6 to 18 inclusive, or to CFY rats from days 6 to 16 inclusive. These findings are consistent with the negative teratogenicity results in mice mutagenicity studies and 3-generation rat reproduction studies already reported.
摘要
在妊娠期间，当以相当于5毫克/千克和15毫克/千克体重的剂量，于第6至18天（含第18天）给新西兰白兔，或于第6至16天（含第16天）给CFY大鼠施用林丹时，未发现有任何致畸作用的证据。这些结果与已报道的小鼠致突变性研究和大鼠三代繁殖研究中的阴性致畸性结果一致。
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