Gottmann K, Lux H D
Department of Neurophysiology, Max-Planck-Institute for Psychiatry, Planegg-Martinsried, Germany.
Perspect Dev Neurobiol. 1995;2(4):371-7.
Voltage-dependent Ca2+ channels appear to constitute a central component of signal transduction cascades in neuronal growth cones. By means of spatially selective superfusion in the subcellular range growth cone, Ca2+ channels were investigated quantitatively. Both principal types of Ca2+ channels, low voltage activated and high voltage activated Ca2+ channels were present in growth cones of cells regenerating neurites in culture as well as growth cones of differentiating neuronal precursor cells. Studies concerning their spatial distribution revealed a remarkable clustering of Ca2+ channels at the growth cone. Their possible functional roles in neurite growth, axonal pathfinding, and synaptogenesis are discussed.
电压依赖性钙通道似乎构成了神经元生长锥信号转导级联反应的核心成分。通过在亚细胞范围内对生长锥进行空间选择性灌流，对钙通道进行了定量研究。在培养中再生神经突的细胞的生长锥以及分化的神经元前体细胞的生长锥中，均存在两种主要类型的钙通道，即低电压激活型和高电压激活型钙通道。关于它们空间分布的研究表明，钙通道在生长锥处有显著的聚集。文中讨论了它们在神经突生长、轴突导向和突触形成中可能的功能作用。
