Martin T J, Braun H, Schmidt R R
Fakultät Chemie, Universität Konstanz, Germany.
Bioorg Med Chem. 1994 Nov;2(11):1203-8. doi: 10.1016/s0968-0896(00)82071-4.
Reaction of sialyl phosphites 2a,b with acetyl-protected ribonucleoside monophosphates 3C, 3U, 3A and 3G furnished without addition of a catalyst directly the corresponding beta-configurated sialyl ribonucleoside monophosphates 4C, 4U, 4A and 4G, respectively. Treatment of these compounds with sodium methanolate in methanol and sodium hydroxide afforded the disodium salts of CMP-Neu5Ac (1C), UMP-Neu5Ac (1U), AMP-Neu5Ac (1A), and GMP-Neu5Ac (1G).
亚磷酸唾液酸酯2a、b与乙酰基保护的核糖核苷单磷酸3C、3U、3A和3G反应，无需添加催化剂，直接分别生成相应的β构型唾液酸核糖核苷单磷酸4C、4U、4A和4G。在甲醇中用甲醇钠和氢氧化钠处理这些化合物，得到CMP-Neu5Ac（1C）、UMP-Neu5Ac（1U）、AMP-Neu5Ac（1A）和GMP-Neu5Ac（1G）的二钠盐。
