Mundell D H, Anselmo C R, Thrupp L D, Wishnow R M
West J Med. 1976 May;124(5):357-60.
Stool specimens were examined from 40 children with diarrhea who were under three years of age to determine the incidence of enterotoxigenic Escherichia coli in endemic diarrhea. Heat-labile E. coli enterotoxin was assayed in the very sensitive and reproducible cultured adrenal tumor cell system. Toxigenic E. coli were isolated from only one stool specimen and in this case infection with Shigella dysenteriae was also present. None of the eight classic enteropathogenic E. coli isolates were positive in the adrenal assay. This study suggests that heat-labile enterotoxin-producing E. coli are not an important cause of endemic childhood diarrhea in Southern California.
对40名3岁以下腹泻儿童的粪便标本进行检测，以确定地方性腹泻中产肠毒素大肠杆菌的发病率。采用极为灵敏且可重复的培养肾上腺肿瘤细胞系统检测不耐热大肠杆菌肠毒素。仅从一份粪便标本中分离出产毒素大肠杆菌，且该病例还存在痢疾志贺菌感染。8株典型的致病性大肠杆菌分离株在肾上腺检测中均为阴性。本研究表明，产不耐热肠毒素的大肠杆菌并非南加州地方性儿童腹泻的重要病因。
