Sonsalla P K
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854, USA.
Drug Alcohol Depend. 1995 Feb;37(2):101-5. doi: 10.1016/0376-8716(94)01064-r.
Although it has been known for several decades that the administration of amphetamines to experimental animals produces damage to monoaminergic neurons, the mechanism(s) underlying this neuropathology is unknown. In recent years, it has been demonstrated that various N-methyl-D-aspartate (NMDA) receptor antagonists can prevent the damage produced by the amphetamines. The purpose of this communication is to review the evidence which demonstrates the role of NMDA receptors in the neuropathology of neostriatal dopaminergic neurons produced by the amphetamines and to discuss how the action of the amphetamines may potentially affect NMDA receptor function.
尽管几十年来人们已经知道给实验动物施用安非他命会对单胺能神经元造成损害，但这种神经病理学的潜在机制尚不清楚。近年来，已经证明各种N-甲基-D-天冬氨酸（NMDA）受体拮抗剂可以预防安非他命产生的损害。本通讯的目的是综述证明NMDA受体在安非他命引起的新纹状体多巴胺能神经元神经病理学中的作用的证据，并讨论安非他命的作用可能如何潜在地影响NMDA受体功能。
