荷马蛋白调节药物诱导的神经可塑性：对成瘾的影响。
Homers regulate drug-induced neuroplasticity: implications for addiction.
作者信息
Szumlinski Karen K, Ary Alexis W, Lominac Kevin D
机构信息
Behavioral and Neural Genetics Laboratory, Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106-9660, USA.
出版信息
Biochem Pharmacol. 2008 Jan 1;75(1):112-33. doi: 10.1016/j.bcp.2007.07.031. Epub 2007 Jul 27.
Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state.
药物成瘾是一种慢性复发性疾病，其特征是对寻求和使用药物有着无法控制的冲动。越来越多的临床和临床前观察结果表明，皮质边缘谷氨酸系统内的病理变化与成瘾表型的遗传易感性及发展有关。这些观察结果表明，调节谷氨酸传递的细胞因子可能是成瘾病因学中的分子候选因素。荷马蛋白家族成员调节谷氨酸受体的信号转导和转运，并维持和调节皮质边缘脑区的细胞外谷氨酸水平。本综述总结了现有数据，这些数据表明荷马蛋白家族与对滥用药物的急性行为和神经化学敏感性、药物诱导的神经可塑性的发展以及与成瘾状态相关的其他行为和认知病理有关。
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