Przetak M M, Yoast S, Schmidt B F
Khepri Pharmaceuticals Inc., South San Francisco, CA 94080, USA.
FEBS Lett. 1995 May 15;364(3):268-71. doi: 10.1016/0014-5793(95)00407-z.
A serine protease gene was cloned from cDNA prepared from tissue isolated from human ascites. The gene codes for a protein of 264 amino acids, identified as human granzyme 3 by the N-terminal amino acid sequence. Granzyme 3 has the expected features of the chymotrypsin family of serine proteases, and is closely related to other human granzymes (40-45% identity). However, the closest granzyme 3 homologue is the recently characterized rat tryptase, RNK-Tryp-2 (75% identity). From Northern blots, granzyme 3 appears to be highly expressed in peripheral blood leukocytes, spleen, thymus, and lung tissues.
