Enk B
Acta Endocrinol (Copenh). 1976 Jun;82(2):312-7. doi: 10.1530/acta.0.0820312.
Twenty-four patients--5 normals, 5 obese subjects, 9 normal weight maturity-onset diabetics and 5 obese maturity-onset diabetics--were subjected to stimulation with the gastro-intestinal hormone secretin (GIH, Stockholm, Sweden). Secretin was administered by rapid intravenous injection 6 times every 30 min in doses increasing from 0.9-90 pmol/kg body weight. Radioimmunological insulin assay and blood glucose determination were carried out. The secretin-induced maximum insulin response rose in all groups with increasing doses. D50 (16 pmol/kg body weight) was identical in all 4 groups. Thus, the diabetic B cells exhibited the same sensitivity to secretin as the normals. Obese subjects already showed a significant insulin response after 0.9 pmol secretin/kg, whereas the response of normal weight subjects did not rise until the dose was 3.6 pmol/kg. This, combined with the normal D50, indicates an increased B cell mass in obese subjects.
24名患者——5名正常人、5名肥胖者、9名正常体重的成年型糖尿病患者和5名肥胖的成年型糖尿病患者——接受了胃肠激素促胰液素（GIH，瑞典斯德哥尔摩）的刺激。促胰液素通过快速静脉注射给药，每30分钟6次，剂量从0.9 - 90 pmol/kg体重递增。进行了放射免疫胰岛素测定和血糖测定。随着剂量增加，促胰液素诱导的最大胰岛素反应在所有组中均升高。所有4组的半数有效剂量（D50，16 pmol/kg体重）相同。因此，糖尿病患者的B细胞对促胰液素的敏感性与正常人相同。肥胖者在促胰液素剂量为0.9 pmol/kg后就已表现出显著的胰岛素反应，而正常体重者直到剂量为3.6 pmol/kg时反应才升高。这与正常的D50相结合，表明肥胖者的B细胞量增加。
