Anger H, Merz E, Gleissenberger H, Dittmar F W
Z Geburtshilfe Perinatol. 1975 Aug;179(4):286-91.
Radio-immunologic measurement of alpha-fetoprotein is possible in small amounts of blood and amniotic fluid. During the first half of pregnancy the AFP values in maternal serum are lowered when there is fetal abnormality (hydatid cyst, immnent abortion). In the second half of pregnancy high values of AFP also indicate danger to the fetus (Rh-incompatibility). The older the pregnancy the AFP values in amniotic fluid fall. In pathologic pregnancy (hydramnion, anencephaly, trisomy) AFP concentration was normal or raised. Measurement of the AFP level in umbilical cord -- blood provides further diagnostic chances: assessment of the duration of pregnancy and, therefore, of fetal maturity.
甲胎蛋白的放射免疫测定可在少量血液和羊水中进行。在妊娠前半期，当胎儿出现异常（葡萄胎囊肿、难免流产）时，母血中的甲胎蛋白值会降低。在妊娠后半期，甲胎蛋白值升高也表明胎儿有危险（Rh血型不相容）。妊娠时间越长，羊水中的甲胎蛋白值越低。在病理性妊娠（羊水过多、无脑儿、三体综合征）中，甲胎蛋白浓度正常或升高。测量脐带血中的甲胎蛋白水平可提供更多诊断机会：评估妊娠持续时间，进而评估胎儿成熟度。
