Evans J, Townsend L
Am J Obstet Gynecol. 1976 Jun 1;125(3):321-7. doi: 10.1016/0002-9378(76)90566-4.
A treatment plan utilizing placebo, cyclical steroid therapy, clomiphene citrate, and human pituitary gonadotropin is outlined for the induction of ovulation in carefully selected potentially fertile women. Such a plan minimizes any risk with the potentially hazardous ovulatory stimulants. A total of 220 patients with secondary amenorrhea were studied and an etiologic basis for the condition was found in 98 (45 per cent). Of the 220, 190 were found suitable for the induction of ovulation, and together with 145 patients with oligomenorrhea and 17 patients with anovulation, entered the treatment plan. Ovulation was successfully induced in 351 of the 352 (99.5 per cent) and pregnancy in 218 (61.9 per cent). The success rates for the agents in the various conditions are presented and discussed.
为精心挑选的潜在可育女性制定了一项利用安慰剂、周期性类固醇疗法、枸橼酸氯米芬和人垂体促性腺激素诱导排卵的治疗方案。这样的方案将使用潜在危险的排卵刺激剂带来的风险降至最低。共研究了220例继发性闭经患者，其中98例（45%）找到了该病的病因。在这220例患者中，发现190例适合诱导排卵，他们与145例月经过少患者和17例无排卵患者一起进入了治疗方案。352例患者中有351例（99.5%）成功诱导排卵，218例（61.9%）怀孕。文中列出并讨论了不同情况下这些药物的成功率。
