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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Schild D, Lischka F W, Restrepo D

Physiologisches Institut, Universität Göttingen, Germany.

J Neurophysiol. 1995 Feb;73(2):862-6. doi: 10.1152/jn.1995.73.2.862.

Effects of inositol-1,4,5-trisphosphate (InsP3) applied through a patch pipette to Xenopus laevis olfactory receptor cells (ORCs) were studied using the patch-clamp technique in conjunction with calcium imaging with fura-2. 2. InsP3 activated, first, a novel voltage-independent Ca2+ current (ICa) and, second, a nonselective cation current (Icat). 3. The activation of these currents occurred at different intracellular calcium concentrations, and the activation of either current led to a marked increase of [Ca2+]i in the dendritic knob. 4. The results suggest that InsP3 might act as a second messenger in vertebrate olfactory receptor cells by activating, through different mechanisms, a plasma membrane Ca2+ conductance (ICa) and a nonselective cation conductance (Icat).

采用膜片钳技术结合fura-2钙成像，研究了通过膜片吸管向非洲爪蟾嗅觉受体细胞（ORC）施加肌醇-1,4,5-三磷酸（InsP3）的效应。2. InsP3首先激活一种新型电压非依赖性Ca2+电流（ICa），其次激活一种非选择性阳离子电流（Icat）。3. 这些电流的激活发生在不同的细胞内钙浓度下，并且任一电流的激活都会导致树突状小体中[Ca2+]i显著增加。4. 结果表明，InsP3可能通过不同机制激活质膜Ca2+电导（ICa）和非选择性阳离子电导（Icat），从而在脊椎动物嗅觉受体细胞中充当第二信使。

Schild D, Lischka F W, Restrepo D

Physiologisches Institut, Universität Göttingen, Germany.

J Neurophysiol. 1995 Feb;73(2):862-6. doi: 10.1152/jn.1995.73.2.862.

Effects of inositol-1,4,5-trisphosphate (InsP3) applied through a patch pipette to Xenopus laevis olfactory receptor cells (ORCs) were studied using the patch-clamp technique in conjunction with calcium imaging with fura-2. 2. InsP3 activated, first, a novel voltage-independent Ca2+ current (ICa) and, second, a nonselective cation current (Icat). 3. The activation of these currents occurred at different intracellular calcium concentrations, and the activation of either current led to a marked increase of [Ca2+]i in the dendritic knob. 4. The results suggest that InsP3 might act as a second messenger in vertebrate olfactory receptor cells by activating, through different mechanisms, a plasma membrane Ca2+ conductance (ICa) and a nonselective cation conductance (Icat).

采用膜片钳技术结合fura-2钙成像，研究了通过膜片吸管向非洲爪蟾嗅觉受体细胞（ORC）施加肌醇-1,4,5-三磷酸（InsP3）的效应。2. InsP3首先激活一种新型电压非依赖性Ca2+电流（ICa），其次激活一种非选择性阳离子电流（Icat）。3. 这些电流的激活发生在不同的细胞内钙浓度下，并且任一电流的激活都会导致树突状小体中[Ca2+]i显著增加。4. 结果表明，InsP3可能通过不同机制激活质膜Ca2+电导（ICa）和非选择性阳离子电导（Icat），从而在脊椎动物嗅觉受体细胞中充当第二信使。