Pérez de Castro I, Santos J, Torres P, Visedo G, Saiz-Ruiz J, Llinares C, Fernández-Piqueras J
Departamento de Biología, Universidad Autonóma de Madrid, Spain.
J Med Genet. 1995 Feb;32(2):131-4. doi: 10.1136/jmg.32.2.131.
Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.
遗传因素在双相情感障碍（BP）的病因学中起着重要作用。到目前为止，连锁研究的结果在很大程度上令人失望。我们在西班牙中部的一个人群中，研究了两个候选基因（酪氨酸羟化酶，TH；多巴胺D2受体基因，DRD2）的多态性DNA标记与双相情感障碍之间可能存在的关联。我们的结果与这两个基因和双相情感障碍之间存在弱关联的情况一致，即TH和DRD2可被视为导致易感性的次要基因。
