Ujházy E, Navarová J, Líska J, Balonová T, Vargová T
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
Methods Find Exp Clin Pharmacol. 1994 Oct;16(8):569-73.
The effect of oral administration of stobadine, a cardioprotective drug, was studied on the basis of determination of selective biochemical parameters in pregnant and lactating rats. Stobadine was administered orally at a dose of 50 mg/kg from day 15 of gestation until day 21 of lactation. We determined creatinine and urea in serum, acidity, protein, glucose, ketones, bilirubin, urobilinogen, blood, and creatinine in urine from females on days 15 and 20 of gestation and 7, 14, and 21 of lactation. In the biochemical parameters investigated no significant differences between control and experimental animals were recorded on any of the days studied. Histopathological examination of kidney tissue did not reveal kidney damage after stobadine administration.
基于对怀孕和哺乳期大鼠选择性生化参数的测定，研究了心脏保护药物司他定口服给药的效果。从妊娠第15天至哺乳期第21天，以50mg/kg的剂量对大鼠口服司他定。我们测定了妊娠第15天和第20天以及哺乳期第7天、第14天和第21天雌性大鼠血清中的肌酐和尿素、酸度、蛋白质、葡萄糖、酮体、胆红素、尿胆原、血液以及尿液中的肌酐。在所研究的任何一天，对照动物和实验动物之间的生化参数均未发现显著差异。司他定给药后，肾脏组织的组织病理学检查未发现肾脏损伤。
