Gleich L L, Wang Z, Pankratov M M, Aretz H T, Shapshay S M
Department of Otolaryngology-Head and Neck Surgery, Burlington, Mass., USA.
Laryngoscope. 1995 May;105(5 Pt 1):494-7. doi: 10.1288/00005537-199505000-00009.
Absorbable sutures have been advocated for tracheal anastomosis to reduce fibrosis and foreign body reaction leading to recurrent stenosis. Fibrin tissue adhesive (FTA) and diode laser welding with indocyanine green-dyed fibrinogen were evaluated in tracheal anastomosis to reduce the number of sutures and to improve healing. In vitro studies demonstrated strong anastomoses with a combination of laser welding and FTA with minimal tissue damage. In a controlled in vivo study, circumferential resections of canine tracheas were repaired with laser welding and FTA augmented with a few stay sutures. These anastomoses had less fibrosis and tissue damage than anastomoses in control animals repaired with sutures alone. This study supports investigation of laser welding and FTA in human beings for tracheal anastomosis and other procedures in which suturing may be difficult.
可吸收缝线已被提倡用于气管吻合术，以减少导致复发性狭窄的纤维化和异物反应。在气管吻合术中评估了纤维蛋白组织粘合剂（FTA）和用吲哚菁绿染色的纤维蛋白原进行的二极管激光焊接，以减少缝线数量并改善愈合。体外研究表明，激光焊接和FTA联合使用可形成牢固的吻合，且组织损伤最小。在一项对照体内研究中，用激光焊接和FTA并辅以几根定位缝线修复犬气管的环形切除。与仅用缝线修复的对照动物的吻合相比，这些吻合处的纤维化和组织损伤更少。这项研究支持在人类中对激光焊接和FTA用于气管吻合术及其他可能难以缝合的手术进行研究。
