Moore J R, Garrido L, Ackerman J L
Department of Radiology, Massachusetts General Hospital, Charlestown 02129, USA.
Magn Reson Med. 1995 Mar;33(3):293-9. doi: 10.1002/mrm.1910330303.
Chemically selective solid state phosphorus-31 nuclear magnetic resonance (NMR) imaging of the mineral phase of bone and synthetic calcium phosphate models for bone mineral is demonstrated with microscopy-scale (about 5 mm field of view) apparatus at 6.0 T magnetic field strength. Pixel-by-pixel linear combination of image data from multiple radio frequency (RF) pulse sequences, chosen to develop contrast between chemical constituents of interest in the mineral, generates derived images showing the distribution of individual constituents. The technique combines the noninvasive character of magnetic resonance imaging (MRI) with the ability of solid state NMR spectroscopy to characterize subtle chemical variations in bone mineral, as well as to measure the amount of mineral. These methods are, in principle, extensible to larger dimensional scales suitable for live animal subjects or human limbs.
在6.0 T磁场强度下，使用显微镜尺度（约5 mm视野）的仪器展示了对骨矿物相和骨矿物合成磷酸钙模型进行化学选择性固态磷-31核磁共振（NMR）成像。从多个射频（RF）脉冲序列获取的图像数据逐像素进行线性组合，这些序列旨在突出矿物中感兴趣化学成分之间的对比度，从而生成显示各个成分分布的派生图像。该技术将磁共振成像（MRI）的非侵入性与固态NMR光谱表征骨矿物细微化学变化以及测量矿物含量的能力相结合。原则上，这些方法可扩展到适用于活体动物或人体肢体的更大尺寸尺度。
