Kwong K K, Wanke I, Donahue K M, Davis T L, Rosen B R
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Magn Reson Med. 1995 Mar;33(3):448-52. doi: 10.1002/mrm.1910330322.
Brain MR signal has been observed to decrease during cessation of breathing due to the increase of deoxyhemoglobin in the blood. However, for both animal and human studies, we have demonstrated that if the subjects breathed 100% oxygen in advance of apnea for a short time, T2*-weighted MR brain signal increased when breathing was stopped for a period of 30-60 s. This demonstrates the possibility of measuring responses to hemodynamic change throughout the entire brain with a single respiratory perturbation in a rapid, reliable, and robust manner.
由于血液中脱氧血红蛋白增加，在呼吸停止期间观察到脑磁共振信号下降。然而，对于动物和人体研究，我们已经证明，如果受试者在呼吸暂停前短时间内吸入100%的氧气，当呼吸停止30 - 60秒时，T2*加权脑磁共振信号会增加。这表明通过单次呼吸扰动，以快速、可靠和稳健的方式测量全脑对血流动力学变化的反应是可能的。
