Marzuk P M, Tardiff K, Leon A C, Hirsch C S, Stajic M, Portera L, Hartwell N, Iqbal M I
Department of Psychiatry, Cornell University Medical College, New York, NY, USA.
N Engl J Med. 1995 Jun 29;332(26):1753-7. doi: 10.1056/NEJM199506293322606.
Cocaine intoxication can lead to fatal cardiovascular and cerebrovascular events. In addition, the neurobehavioral effects of cocaine may increase the likelihood that a user will receive violent fatal injuries. Since New York City is a center for the importation and distribution of cocaine, we sought to determine the extent of cocaine use among city residents with fatal injuries.
Among a total of 14,843 residents of New York City who received fatal injuries from 1990 through 1992, we determined the proportion who used cocaine shortly before their deaths. We also determined the population-based rates of fatal injuries that were known to follow cocaine use and the proportion of all deaths of New York City residents that was represented by these cases for each demographic stratum. For adults 15 to 44 years of age, fatal injury after cocaine use was ranked with other causes of death as though it was a separate cause.
Cocaine use, as measured by the detection of the metabolite benzoylecgonine in urine or blood, was found in 26.7 percent of all New York City residents receiving fatal injuries; free cocaine was detected in 18.3 percent. Approximately one third of deaths after cocaine use were the result of drug intoxication, but two thirds involved traumatic injuries resulting from homicides, suicides, traffic accidents, and falls. If fatal injury after cocaine use was considered as a separate cause of death, it would rank among the five leading causes of death among those 15 to 44 years of age in New York City.
Fatal injuries among cocaine users account for a substantial proportion of all deaths among young adults in New York City.
可卡因中毒可导致致命的心血管和脑血管事件。此外,可卡因的神经行为效应可能会增加使用者遭受暴力致命伤害的可能性。由于纽约市是可卡因进口和分销的中心,我们试图确定在遭受致命伤害的城市居民中可卡因的使用程度。
在1990年至1992年期间接受致命伤害的总共14843名纽约市居民中,我们确定了在死亡前不久使用可卡因的居民比例。我们还确定了已知由可卡因使用导致的基于人群的致命伤害发生率,以及这些案例在每个人口统计学阶层中占纽约市居民所有死亡人数的比例。对于15至44岁的成年人,可卡因使用后的致命伤害与其他死亡原因一起排名,就好像它是一个单独的原因一样。
通过检测尿液或血液中的代谢物苯甲酰爱康宁来衡量,在所有遭受致命伤害的纽约市居民中,26.7%的人被发现使用过可卡因;18.3%的人检测出游离可卡因。可卡因使用后约三分之一的死亡是药物中毒的结果,但三分之二涉及凶杀、自杀、交通事故和跌倒导致的创伤性伤害。如果将可卡因使用后的致命伤害视为一个单独的死亡原因,它将在纽约市15至44岁人群的五大主要死因中排名。
可卡因使用者的致命伤害在纽约市年轻成年人的所有死亡中占很大比例。