Cheever A W, Finkelman F D, Cox T M
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Parasite Immunol. 1995 Feb;17(2):103-9. doi: 10.1111/j.1365-3024.1995.tb00972.x.
Anti-interleukin-4 (IL-4) treatment of Schistosoma japonicum-infected mice markedly inhibited in vitro secretion of the Th2 cytokines IL-4 and IL-5 from antigen-stimulated spleen cells, but enhanced the secretion of the Th1 cytokine IFN-gamma. IL-2 secretion was unaffected. Hepatic fibrosis was markedly diminished in anti-IL-4-treated-mice at ten weeks of infection while granulomas around S. japonicum eggs in the livers were slightly-to-moderately increased in size. The number of eggs per worm pair in the tissues and feces did not differ significantly in treated and untreated mice. These findings suggest that Th2 cytokine responses are important in the genesis of schistosomal hepatic fibrosis.
用抗白细胞介素-4（IL-4）治疗日本血吸虫感染的小鼠，可显著抑制抗原刺激的脾细胞在体外分泌Th2细胞因子IL-4和IL-5，但增强Th1细胞因子IFN-γ的分泌。IL-2的分泌未受影响。在感染10周时，抗IL-4治疗的小鼠肝纤维化明显减轻，而肝脏中日本血吸虫卵周围的肉芽肿大小略有至中度增加。治疗组和未治疗组小鼠组织和粪便中每对虫体的虫卵数量无显著差异。这些发现表明，Th2细胞因子反应在血吸虫性肝纤维化的发生中起重要作用。
