Le Bouëdec G, Buono J P, De Latour M, Toledano E, Vergote T, Dauplat J
Centre Jean Perrin, Clermont-Ferrand.
Presse Med. 1995 Apr 1;24(13):639-41.
Two women (63 and 68 years) presented with primary angiosarcomas of the skin which had developed on an area of chronic lymphoedema after radiosurgical treatment for breast cancer 4 and 13 years earlier. Immunohistochemistry tests formally eliminated epithelial metastasis and produced evidence in favour of lymphatic or capillary vascular proliferation. Endothelial affinity for anti-factor VIII and positive tests for certain markers of intermediary filaments (actin, vimentin) confirmed the vascular and conjunctive tissue origin of the tumours.
两名女性(分别为63岁和68岁)患原发性皮肤血管肉瘤,肿瘤分别发生在4年前和13年前因乳腺癌接受放射外科治疗后出现的慢性淋巴水肿区域。免疫组织化学检测正式排除了上皮转移,并提供了支持淋巴管或毛细血管增生的证据。内皮细胞对抗凝血因子VIII的亲和力以及中间丝某些标志物(肌动蛋白、波形蛋白)的阳性检测结果证实了肿瘤的血管和结缔组织起源。