Fernández A, Verde M T, Gomez J, Gascon M, Ramos J J
Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, Spain.
Res Vet Sci. 1995 Mar;58(2):119-22. doi: 10.1016/0034-5288(95)90063-2.
Two groups of 32 laying hens and two groups of 32, 23-day-old broiler chickens were given 2.5 and 5 mg kg-1 of aflatoxin in their diet for four, eight, 16 and 32 days; 16 hens and 32 broiler chicks served as control groups. In the laying hens, aflatoxicosis was characterised mainly by an increase in prothrombin time, and decreases in total plasma proteins and albumin levels; there were increases in red blood cell (RBC) counts and haematocrit which were greater in the group fed 5 mg kg-1. There was a decrease in beta-globulins and an increase in gamma-globulins. In the broiler chickens, there was only a slight increase in prothrombin time and a decrease in RBC counts. This data proves the good sensitivity and utility of prothrombin time values as an indicator of aflatoxicosis in birds.
将两组32只产蛋母鸡和两组32只23日龄的肉鸡，在其日粮中分别添加2.5毫克/千克和5毫克/千克的黄曲霉毒素，持续4天、8天、16天和32天；16只母鸡和32只肉鸡雏作为对照组。在产蛋母鸡中，黄曲霉毒素中毒主要表现为凝血酶原时间延长，血浆总蛋白和白蛋白水平降低；红细胞（RBC）计数和血细胞比容增加，在饲喂5毫克/千克组中增加更为明显。β-球蛋白减少，γ-球蛋白增加。在肉鸡中，凝血酶原时间仅略有增加，红细胞计数减少。该数据证明了凝血酶原时间值作为禽类黄曲霉毒素中毒指标具有良好的敏感性和实用性。
