Jürgens C, Porte T, Wolter D, Schmidt H G, Kricheldorf H R, Kreiser-Saunders I
Abteilung für Unfall- und Wiederherstellungschirurgie, Berufsgenossenschaftliches Unfallkrankenhaus Hamburg.
Unfallchirurg. 1995 Apr;98(4):233-40.
Most of the temporary dressings used in the treatment of burns do not meet the objectives of a skin substitute concerning application, safety and comfort. Removal is often painful and traumatic and increases the risk of infection. Biodegradable polymers of lactic and caproic acid were developed as part of a research programme (BMFT/FRG 01 KG 8809/7), and chemical and physical properties were investigated. Films made of the copolymer material were characterized by structure, transparency, permeability, tensile strength, flexibility and degradation. The transparent films appeared increasingly opaque during hydrolysis. The water vapour permeance could be varied between 40 and 250 (40-136) ml/m2 per h (according to the method of measurement). The mechanical properties are characterized by a maximum elongation of > 2000% at 37 degrees C and a very low elastically modulus. When the results were compared with those of three established film dressings, no restriction was found in the aptitude of the material as a wound dressing.
用于烧伤治疗的大多数临时敷料在应用、安全性和舒适性方面未达到皮肤替代物的目标。去除敷料通常很痛苦且具有创伤性，还会增加感染风险。作为一项研究计划（德国联邦教研部/联邦德国 01 KG 8809/7）的一部分，研发了乳酸和己酸的可生物降解聚合物，并对其化学和物理性质进行了研究。由共聚物材料制成的薄膜通过结构、透明度、渗透性、拉伸强度、柔韧性和降解性进行表征。在水解过程中，透明薄膜变得越来越不透明。水蒸气透过率可在每小时 40 至 250（40 - 136）毫升/平方米之间变化（根据测量方法）。机械性能的特征是在 37 摄氏度时最大伸长率>2000%且弹性模量非常低。当将结果与三种已确立的薄膜敷料的结果进行比较时，未发现该材料作为伤口敷料的适用性存在限制。
