Jürgens C, Beuchel M, Bisgwa F, Dekker A, Hafemann B, Kortmann H R, Niendorf A, Partecke B D, Porte T, Schultz J H
Abteilung für Unfall- und Wiederherstellungschirurgie, Berufsgenossenschaftliches Unfalkrankenhaus Hamburg.
Unfallchirurg. 1995 Apr;98(4):241-7.
The major advantage of biodegradable synthetic wound dressings compared to other synthetic materials and biological tissue derivatives is avoidance of the necessity to change the dressing. The copolymer films used in this study were made of lactic and caproic acid. They pose no problems concerning immunology or transmission of diseases. Moreover, the substances released by degradation may possibly influence the process of wound healing. The material proved to be non-toxic and was used successfully as a carrier for cell culture with keratinocytes. The permeability for bacteria is determined by degradation. Evaluation of the bacteriological studies indicates secure protection against secondary contamination of the films for at least 15 days, however. Concerning application, dressing properties, wound healing and wound retraction, no disadvantages were found in comparison with the results of the competition's film Opsite. Based on these findings, the films are now used in a clinical study as a wound dressing for split-skin donor sites.
与其他合成材料和生物组织衍生物相比，可生物降解合成伤口敷料的主要优点是无需更换敷料。本研究中使用的共聚物薄膜由乳酸和己酸制成。它们在免疫学或疾病传播方面不存在问题。此外，降解释放的物质可能会影响伤口愈合过程。该材料被证明无毒，并成功用作角质形成细胞细胞培养的载体。细菌的渗透性由降解决定。然而，细菌学研究的评估表明，这些薄膜至少能安全保护15天以防二次污染。在应用、敷料特性、伤口愈合和伤口回缩方面，与竞争产品Opsite薄膜的结果相比，未发现任何缺点。基于这些发现，这些薄膜目前正在一项临床研究中用作供皮区伤口敷料。
