阿尔茨海默病淀粉样前体蛋白的加工与分泌
Processing and secretion of Alzheimer's disease amyloid precursor protein.
作者信息
Kinbara K, Kitagaki H, Kinouchi T, Okano M, Sorimachi H, Ishiura S, Suzuki K
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
Tohoku J Exp Med. 1994 Nov;174(3):209-16. doi: 10.1620/tjem.174.209.
PMID:7761986
Abstract
We studied in vivo expression and in vitro secretion of the Alzheimer's disease amyloid precursor protein (APP). The results indicate that secretion of APP is mediated by PKC and the initial step of the processing may occur in the acidic secretory granules of the glial cells. Our results suggest that a metabolic switch of APP in neural cells is critical in amyloid deposition.
摘要
我们研究了阿尔茨海默病淀粉样前体蛋白（APP）的体内表达和体外分泌。结果表明，APP的分泌由蛋白激酶C（PKC）介导，且加工的起始步骤可能发生在神经胶质细胞的酸性分泌颗粒中。我们的结果表明，神经细胞中APP的代谢转换在淀粉样蛋白沉积中至关重要。
相似文献
1
Processing and secretion of Alzheimer's disease amyloid precursor protein.阿尔茨海默病淀粉样前体蛋白的加工与分泌
Tohoku J Exp Med. 1994 Nov;174(3):209-16. doi: 10.1620/tjem.174.209.
2
Amyloid beta/A4 precursor protein (APP) processing in lysosomes.溶酶体中β淀粉样蛋白/A4前体蛋白（APP）的加工过程。
Ann N Y Acad Sci. 1992 Dec 31;674:129-37. doi: 10.1111/j.1749-6632.1992.tb27482.x.
3
The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition.与家族性阿尔茨海默病相关的淀粉样β蛋白前体突变会以促进淀粉样蛋白沉积的方式改变加工过程。
Tohoku J Exp Med. 1994 Nov;174(3):217-23. doi: 10.1620/tjem.174.217.
4
Amyloid precursor protein processing in vivo--insights from a chemically-induced constitutive overactivation of protein kinase C in Guinea pig brain.体内淀粉样前体蛋白的加工——来自化学诱导豚鼠脑内蛋白激酶C组成性过度激活的见解
Curr Med Chem. 2003 May;10(10):871-82. doi: 10.2174/0929867033457692.
5
Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.淀粉样前体蛋白羧基末端片段的磷酸化通过γ-分泌酶依赖性机制增强其加工过程。
Neurobiol Dis. 2005 Nov;20(2):625-37. doi: 10.1016/j.nbd.2005.05.004. Epub 2005 Jun 3.
6
Characterization of beta-secretase.β-分泌酶的特性分析
Biochem Soc Trans. 1998 Aug;26(3):500-4. doi: 10.1042/bst0260500.
7
Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease.血管加压素和缓激肽调节阿尔茨海默病淀粉样蛋白前体的分泌加工过程。
Neurochem Res. 1998 May;23(5):807-14. doi: 10.1023/a:1022423813362.
8
The molecular pathology of amyloid deposition in Alzheimer's disease.阿尔茨海默病中淀粉样蛋白沉积的分子病理学
Mol Neurobiol. 1991;5(2-4):389-98. doi: 10.1007/BF02935560.
9
Generation of amyloid beta protein from its precursor is sequence specific.由其前体生成β淀粉样蛋白具有序列特异性。
Neuron. 1995 Mar;14(3):661-70. doi: 10.1016/0896-6273(95)90323-2.
10
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.淀粉样前体蛋白向β淀粉样肽的溶酶体加工过程：组织蛋白酶S的独特作用。
Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):299-305. doi: 10.1042/bj3110299.
Zotero 插件