Kinbara K, Kitagaki H, Kinouchi T, Okano M, Sorimachi H, Ishiura S, Suzuki K
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Tohoku J Exp Med. 1994 Nov;174(3):209-16. doi: 10.1620/tjem.174.209.
We studied in vivo expression and in vitro secretion of the Alzheimer's disease amyloid precursor protein (APP). The results indicate that secretion of APP is mediated by PKC and the initial step of the processing may occur in the acidic secretory granules of the glial cells. Our results suggest that a metabolic switch of APP in neural cells is critical in amyloid deposition.
我们研究了阿尔茨海默病淀粉样前体蛋白（APP）的体内表达和体外分泌。结果表明，APP的分泌由蛋白激酶C（PKC）介导，且加工的起始步骤可能发生在神经胶质细胞的酸性分泌颗粒中。我们的结果表明，神经细胞中APP的代谢转换在淀粉样蛋白沉积中至关重要。
