阿尔茨海默病中淀粉样蛋白沉积的分子病理学 - Suppr

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The molecular pathology of amyloid deposition in Alzheimer's disease.

作者信息

Martins R N, Robinson P J, Chleboun J O, Beyreuther K, Masters C L

机构信息

University Department of Surgery, Repatriation General Hospital, Hollywood, Perth, Western Australia.

出版信息

Mol Neurobiol. 1991;5(2-4):389-98. doi: 10.1007/BF02935560.

DOI:10.1007/BF02935560

PMID:1823142

Abstract

摘要

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The molecular pathology of amyloid deposition in Alzheimer's disease.阿尔茨海默病中淀粉样蛋白沉积的分子病理学

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Generation of amyloid beta protein from its precursor is sequence specific.由其前体生成β淀粉样蛋白具有序列特异性。

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The Alzheimer's plaques, tangles and memory deficits may have a common origin; part I; a calcium deficit hypothesis.阿尔茨海默病的斑块、缠结和记忆缺陷可能有共同起源；第一部分；钙缺乏假说。

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The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition.与家族性阿尔茨海默病相关的淀粉样β蛋白前体突变会以促进淀粉样蛋白沉积的方式改变加工过程。

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Development and evaluation of compounds for imaging of beta-amyloid plaque by means of positron emission tomography.用于通过正电子发射断层扫描对β-淀粉样蛋白斑块进行成像的化合物的研发与评估。

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本文引用的文献

ISOLATION OF A CRYSTALLINE PROTEIN COMPOUND OF TRYPSIN AND OF SOYBEAN TRYPSIN-INHIBITOR.胰蛋白酶与大豆胰蛋白酶抑制剂的结晶蛋白化合物的分离。

J Gen Physiol. 1947 Mar 20;30(4):311-20. doi: 10.1085/jgp.30.4.311.

Protein inhibitors of proteinases.蛋白酶的蛋白质抑制剂。

Annu Rev Biochem. 1980;49:593-626. doi: 10.1146/annurev.bi.49.070180.003113.

The isolation and amino acid composition of senile plaque core protein.老年斑核心蛋白的分离及氨基酸组成

Brain Res. 1983 Jan 24;259(2):348-52. doi: 10.1016/0006-8993(83)91273-8.

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.阿尔茨海默病：一种新型脑血管淀粉样蛋白的纯化与特性的初步报告

Biochem Biophys Res Commun. 1984 May 16;120(3):885-90. doi: 10.1016/s0006-291x(84)80190-4.

Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein.阿尔茨海默病与唐氏综合征：一种独特的脑血管淀粉样原纤维蛋白的共性

Biochem Biophys Res Commun. 1984 Aug 16;122(3):1131-5. doi: 10.1016/0006-291x(84)91209-9.

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.大脑淀粉样蛋白的神经元起源：阿尔茨海默病的神经原纤维缠结与斑块核心及血管淀粉样蛋白含有相同蛋白质。

EMBO J. 1985 Nov;4(11):2757-63. doi: 10.1002/j.1460-2075.1985.tb04000.x.

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.一种编码阿尔茨海默病脑淀粉样蛋白的cDNA的特性及染色体定位

Science. 1987 Feb 20;235(4791):877-80. doi: 10.1126/science.3810169.

The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16.人类淀粉样β蛋白（AD-AP）基因的小鼠同源基因位于小鼠16号染色体的远端：人类21号染色体与小鼠16号染色体之间同源性的进一步延伸。

Biochem Biophys Res Commun. 1987 Apr 29;144(2):1069-75. doi: 10.1016/s0006-291x(87)80073-6.

Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease.从阿尔茨海默病淀粉样斑块纤维中分离低分子量蛋白质。

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Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence.关岛帕金森病-痴呆综合征和阿尔茨海默病神经原纤维缠结中的淀粉样蛋白具有相同的氨基酸序列。

Proc Natl Acad Sci U S A. 1987 Apr;84(7):2073-7. doi: 10.1073/pnas.84.7.2073.

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