Iagubov A S
Biull Eksp Biol Med. 1975 Oct;80(10):99-102.
Morphometry was applied to the study of the fine structure of the mitochondria, ergastoplasma and polyribosomal apparatus of the cells of the primary and continuous cultures of the tumour tissues. Both among the primary and among the continuous cultures there can be found marked differences in the fine structure of the cells of individual strains. However, as a whole these groups displayed a significant difference by organization of the cytoplasmic protein-synthesizing apparatus. Of the continuous cultures characteristic is a more reduced ergastoplasm and more marked polyribosomal apparatus. It can be supposed that for the tumour cells cultivation on glass served as a factor promoting a further reconstruction of the protein-synthesizing apparatus on the synthesis of the substrates necessary for the growth and multiplication of the cell mass.
形态测量学被应用于肿瘤组织原代培养和连续培养细胞中线粒体、内质网和多核糖体装置精细结构的研究。在原代培养物和连续培养物中,均可发现个别菌株细胞的精细结构存在显著差异。然而,总体而言,这些组在细胞质蛋白质合成装置的组织方面表现出显著差异。连续培养物的特征是内质网更不发达,多核糖体装置更明显。可以推测,对于肿瘤细胞来说,在玻璃上培养是促进蛋白质合成装置在合成细胞群体生长和增殖所需底物时进一步重建的一个因素。