柳氮磺胺吡啶对类风湿关节炎全身免疫和黏膜免疫的不同作用的证据。
Evidence for differential effects of sulphasalazine on systemic and mucosal immunity in rheumatoid arthritis.
作者信息
Kanerud L, Engström G N, Tarkowski A
机构信息
Department of Rheumatology, Karolinska Institute, Stockholm Söder Hospital, Sweden.
出版信息
Ann Rheum Dis. 1995 Apr;54(4):256-62. doi: 10.1136/ard.54.4.256.
OBJECTIVE
To study the effects of sulphasalazine (SASP) on the systemic and mucosal humoral immune systems in patients with rheumatoid arthritis (RA).
METHODS
Serum concentrations of interleukin 6 (IL-6), class and subclass specific IgG, IgA and IgM, IgA and IgG antigliadin antibodies and rheumatoid factors (RF) of IgG, IgA (including IgA1 and IgA2 subclasses) and IgM isotypes were measured before and 16 weeks after sulphasalazine (SASP) therapy in 15 female and three male patients with RA. Amounts of immunoglobulins in saliva and jejunal fluid were measured as estimates of mucosal humoral immunity.
RESULTS
Serum concentrations of IgA and IgG decreased significantly during SASP therapy and correlated with reduced concentrations of IL-6. In addition, levels of circulating IgA RF, IgA anti-gliadin antibodies and IgM RF decreased significantly after the treatment. In contrast, immunoglobulin levels in saliva and jejunal fluid were unaltered.
CONCLUSION
SASP exerts powerful but selective inhibitory effects on systemic immunoglobulin production, whereas no effects on mucosal immunoglobulin production were observed. The decreased systemic B cell activity may be mediated by downregulation of the production of IL-6, a cytokine with Ig switching properties.
目的
研究柳氮磺胺吡啶（SASP）对类风湿关节炎（RA）患者全身和黏膜体液免疫系统的影响。
方法
检测15例女性和3例男性RA患者在接受柳氮磺胺吡啶（SASP）治疗前及治疗16周后的血清白细胞介素6（IL-6）浓度、类及亚类特异性IgG、IgA和IgM、IgA和IgG抗麦醇溶蛋白抗体以及IgG、IgA（包括IgA1和IgA2亚类）和IgM同种型类风湿因子（RF）。检测唾液和空肠液中的免疫球蛋白量，作为黏膜体液免疫的评估指标。
结果
在SASP治疗期间，血清IgA和IgG浓度显著降低，且与IL-6浓度降低相关。此外，治疗后循环中的IgA RF、IgA抗麦醇溶蛋白抗体和IgM RF水平显著降低。相比之下，唾液和空肠液中的免疫球蛋白水平未改变。
结论
SASP对全身免疫球蛋白产生具有强大但选择性的抑制作用，而未观察到对黏膜免疫球蛋白产生的影响。全身B细胞活性降低可能是由具有Ig转换特性的细胞因子IL-6产生下调介导的。
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