Binder J R, Rao S M, Hammeke T A, Frost J A, Bandettini P A, Jesmanowicz A, Hyde J S
Department of Neurology, Medical College of Wisconsin, Milwaukee, USA.
Arch Neurol. 1995 Jun;52(6):593-601. doi: 10.1001/archneur.1995.00540300067015.
To develop a procedure for noninvasive measurement of language lateralization with functional magnetic resonance imaging (MRI).
Functional neuroimaging using time-series echo-planar MRI.
University medical center research facility.
Five healthy, right-handed, young adults.
Number of MRI voxels in left and right hemispheres showing task-related signal increases during two contrasting auditory processing tasks. The nonlinguistic task involved processing of pure tones, while the linguistic task involved processing of single words based on semantic content.
The pure-tone processing task activated temporal lobe auditory areas and dorsolateral frontal regions bilaterally. Using this task as a control condition, the semantic processing task resulted in lateralized activity in distributed regions of the left hemisphere. A significant effect of task on intrahemispheric activity pattern was demonstrated in every subject. Results were reproduced in preliminary studies of test-retest reliability.
The results demonstrate the lateralized anatomy of semantic linguistic systems in contrast to non-linguistic auditory sensory processors and introduce a task subtraction technique adapted for functional MRI as a noninvasive measure of language lateralization.
开发一种利用功能磁共振成像（MRI）进行语言侧化非侵入性测量的方法。
使用时间序列回波平面MRI进行功能神经成像。
大学医学中心研究机构。
五名健康的右利手年轻成年人。
在两项对比性听觉处理任务期间，左右半球显示与任务相关信号增加的MRI体素数量。非语言任务涉及纯音处理，而语言任务涉及基于语义内容的单字处理。
纯音处理任务双侧激活颞叶听觉区域和背外侧额叶区域。以该任务作为对照条件，语义处理任务在左半球的分布区域产生了侧化活动。在每个受试者中均显示任务对半球内活动模式有显著影响。在重测信度的初步研究中重现了结果。
结果表明语义语言系统与非语言听觉感觉处理器相比具有侧化解剖结构，并引入了一种适用于功能MRI的任务减法技术作为语言侧化的非侵入性测量方法。
