Inhibition of glycogen synthase kinase-3 by insulin in cultured human skeletal muscle myoblasts.
作者信息
Borthwick A C, Wells A M, Rochford J J, Hurel S J, Turnbull D M, Yeaman S J
机构信息
Department of Biochemistry, University of Newcastle upon Tyne, UK.
出版信息
Biochem Biophys Res Commun. 1995 May 25;210(3):738-45. doi: 10.1006/bbrc.1995.1721.
PMID:7763247
Abstract
The acute effects of insulin on the activity of glycogen synthase kinase 3 (GSK-3) have been investigated both in the rat L6 muscle cell line and in cultured human myoblasts. The alpha and beta isoforms of GSK-3 are present in both cell types, with the beta isoform being predominant in the human cells. Insulin causes a rapid inactivation of both isoforms in both cell lines, with 50% inactivation being observed in the human myoblasts.
摘要
Zotero 插件