工程化革兰氏阴性菌细胞表面的实际应用。

Practical applications of engineering gram-negative bacterial cell surfaces.

作者信息

Georgiou G, Poetschke H L, Stathopoulos C, Francisco J A

机构信息

Department of Chemical Engineering, University of Texas, Austin 78712.

出版信息

Trends Biotechnol. 1993 Jan;11(1):6-10. doi: 10.1016/0167-7799(93)90068-K.

DOI:10.1016/0167-7799(93)90068-K

PMID:7763382

Abstract

The recent development of systems for the expression of heterologous proteins on the surface of Gram-negative bacteria has stimulated considerable interest in practical applications. Areas in which surface expression is particularly important include the development of live bacterial vaccines, the display and selection of peptide and antibody libraries, the production of whole cell adsorbents, and the preparation of microbial biocatalysts.

摘要

革兰氏阴性菌表面异源蛋白表达系统的最新进展激发了人们对其实际应用的浓厚兴趣。表面表达尤为重要的领域包括活细菌疫苗的开发、肽库和抗体库的展示与筛选、全细胞吸附剂的生产以及微生物生物催化剂的制备。