Bódalo Santoyo A, Gómez Carrasco J L, Gómez Gómez E, Bastida Rodríguez J, Martínez Morales E
Department of Chemical Engineering, Faculty of Sciences, University of Murcia, Spain.
Biotechnol Prog. 1993 Mar-Apr;9(2):166-73. doi: 10.1021/bp00020a008.
A mathematical model applicable to the analysis, design, and simulation of heterogeneous enzymatic processes reacting in a stirred-tank reactor has been formulated. The model develops the unsteady-state design equations for such reactors and also the diffusion reaction equation in the spherical catalyst particles for reversible Michaelis-Menten kinetics. This structured general model provides an overview of almost all of the processes occurring in an immobilized enzyme reactor system. Although the analysis presented here is limited to certain situations, it can be extended to other support geometries, enzyme kinetics, and reactor configurations. To check the model, the experimental data obtained with immobilized beta-galactosidase were compared to those theoretically predicted.
已建立了一个适用于分析、设计和模拟在搅拌釜式反应器中发生的非均相酶促过程的数学模型。该模型推导了此类反应器的非稳态设计方程以及球形催化剂颗粒中可逆米氏动力学的扩散反应方程。这个结构化的通用模型概述了固定化酶反应器系统中几乎所有发生的过程。尽管此处给出的分析限于某些情况，但它可以扩展到其他载体几何形状、酶动力学和反应器配置。为了检验该模型，将固定化β-半乳糖苷酶获得的实验数据与理论预测数据进行了比较。
