小脑神经元：兴奋性毒性处理敏感性的分化与调节
Cerebellar neurones: differentiation and modulation of sensitivity to excitotoxic treatment.
作者信息
Mercanti D, Angelini A, Ciotti M T, Eboli M L, Galli C, Battistini L, Merlo D, Calissano P
机构信息
CNR-Institute of Neurobiology, Roma, Italy.
出版信息
Cytotechnology. 1993;11 Suppl 1:S117-9.
The neurite outgrowth and adhesion complex (NOAC), isolated from rabbit sera has been dissociated in its major components by reverse-phase chromatography in HPLC by using a C18 column. SDS-PAGE analysis of the active fractions revealed the presence of three major bands of approximately 100, 70 and 50 kDa. Studies on the biological activity of NOAC were carried out on rat cerebellar granule cells. NOAC-cultured cells exhibit a marked resistance to excitotoxic stimuli carried by glutamate.
从兔血清中分离出的神经突生长与黏附复合物（NOAC），通过使用C18柱的高效液相色谱反相色谱法已被分离成其主要成分。对活性组分的SDS-PAGE分析显示存在三条主要条带，分子量约为100、70和50 kDa。在大鼠小脑颗粒细胞上进行了NOAC生物活性的研究。用NOAC培养的细胞对谷氨酸携带的兴奋性毒性刺激表现出显著抗性。
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