Sabbioni E, Pozzi G, Fischbach M, Bahbouth E
Commission of the European Communities, Environment Institute, Joint Research Centre, Varese, Italy.
Cytotechnology. 1993;11 Suppl 1:S24-6.
This paper reviews the JRC-Ispra research activity on toxicological studies related to the environmental and occupational exposure of trace metals, as carried out by a combination of cell culture methodologies with nuclear and radioanalytical techniques. Applications concern the setting of uptake-effect relationships and the study of the mechanisms of toxicity of specific metals (Al, As, Cd, Co, Cr, Mo, Se, V), as well as the establishment of ranking of metal toxicity by carrying out systematic studies (screening tests).
本文综述了联合研究中心-伊斯普拉（JRC-Ispra）关于与痕量金属环境和职业暴露相关的毒理学研究的活动，这些研究通过细胞培养方法与核分析和放射分析技术相结合来开展。其应用涉及确定吸收-效应关系、研究特定金属（铝、砷、镉、钴、铬、钼、硒、钒）的毒性机制，以及通过开展系统研究（筛选试验）来确定金属毒性的排名。
