Environment Institute Joint Research Centre, Ispra Site, Commission of the European Communities, 21020, Ispra Varese, Italy.
Cytotechnology. 1993 Jan;11(Suppl 1):S24-6. doi: 10.1007/BF00746046.
This paper reviews the JRC-Ispra research activity on toxicological studies related to the environmental and occupational exposure of trace metals, as carried out by a combination of cell culture methodologies with nuclear and radioanalytical techniques.Applications concern the setting of uptake-effect relationships and the study of the mechanisms of toxicity of specific metals (Al, As, Cd, Co, Cr, Mo, Se, V), as well as the establishment of ranking of metal toxicity by carrying out systematic studies (screening tests).
本文回顾了 JRC-Ispra 研究所进行的有关痕量金属环境和职业暴露的毒理学研究活动，该研究结合了细胞培养方法和核与放射性分析技术。应用涉及摄取-效应关系的建立和特定金属（铝、砷、镉、钴、铬、钼、硒、钒）毒性机制的研究，以及通过系统研究（筛选试验）确定金属毒性的排序。
