甲病毒——用于表达异源基因的载体。
Alphaviruses--vectors for the expression of heterologous genes.
作者信息
Schlesinger S
机构信息
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110-1093.
出版信息
Trends Biotechnol. 1993 Jan;11(1):18-22. doi: 10.1016/0167-7799(93)90070-P.
Abstract
DNA viruses and retroviruses are well established as vectors for the expression of heterologous genes, but there is increasing interest in the possibilities of using RNA viruses, which do not replicate through a DNA intermediate, for this purpose. This article summarizes some of the general properties of RNA viruses and concentrates on one class of RNA viruses--the alphaviruses--and their potential as expression vectors.
摘要
DNA病毒和逆转录病毒作为异源基因表达载体已得到广泛应用，但人们对使用不以DNA为中间媒介进行复制的RNA病毒作为表达载体的可能性越来越感兴趣。本文总结了RNA病毒的一些一般特性，并着重介绍了一类RNA病毒——甲病毒——及其作为表达载体的潜力。
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