Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo.
作者信息
Yamaguchi K, Sasano A, Urakami T, Tsuji T, Kondo K
机构信息
Sagami Chemical Research Center, Kanagawa, Japan.
出版信息
Biosci Biotechnol Biochem. 1993 Jul;57(7):1231-3. doi: 10.1271/bbb.57.1231.
PMID:7764070
Abstract
Pyrroloquinoline quinone (PQQ), which is a cofactor of microbial quinoprotein enzymes, was found to be a potent enhancer of nerve growth factor (NGF) production in vitro. One of PQQ derivatives, oxazopyrroloquinoline trimethylester, had little activity in vitro, but increased the NGF content in rat brain in vivo.
摘要
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